Liquid Cytology

Liquid-based cytology is a method of preparing samples for examination in cytopathology. The sample is collected, normally by a small brush, in the same way as for a conventional smear test, but rather than the smear being transferred directly to a microscope slide, the sample is deposited into a small bottle of preservative liquid.

Cytopathology, a branch of pathology, deals with manifestations of disease at the cellular level. Liquid-based cytology is a method of preparing samples for examination in cytopathology.

Liquid-based cytology is an alternative to the Pap test (smear test). Both form part of a cervical cancer screening that can also include an HPV test and physical pelvis examination. The goal of a cervical screening is to check for abnormal cervical cells that could be precancerous/cancerous and diagnose abnormal cells and provide treatment if necessary. Regular (as required) screening helps reduce the incidence of cervical cancer and mortality.

What Happens During Liquid-based Cytology

Like a Pap smear, Liquid-based Cytology (LBC) involves collecting (‘scraping’) a sample of cells from the surface of the cervix.

A small brush is used to collect the cells (a spatula in the case of a Pap smear). Cells from LBC remain on the head of the brush which gets broken off and placed into a small pot of liquid that goes to a lab. Cells collected during a Pap smear are transferred to a microscope slide and sent to a lab. Once at a lab, a careful examination takes place. Once complete, results are communicated to the healthcare professional who then informs the patient. Results fall into the following categories: